HIV Reservoir in the Brain Doesn’t Respond to Treatment Intensification

Adding a new antiretroviral (ARV) drug with the ability to penetrate into the brain to an existing regimen doesn’t reduce residual HIV in the brain or brain inflammation in people who have good suppression of HIV elsewhere in the body, according to a study published in the December 15 issue of the Journal of Acquired Immune Deficiency Syndromes. These data suggest that the brain does serve as a protected reservoir of HIV infected cells, and that simply adding ARVs that penetrate into the central nervous system (CNS) may not shut down residual virus or reduce brain cell inflammation.

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